What is Apisterone™? The complete guide

The search for never-ending gains has led researchers on a quest to identify compounds that enhance muscle protein synthesis, boost muscle growth, and enhance recovery. Over the years, scientists have stumbled across a number of intriguing anabolic agents, such as laxogenin or epicatechin.

Recently, they’ve uncovered another novel muscle building supplement in Apisterone™ (Apigenin).

Derived from Chrysanthemum morifolium, Apisterone™ (Apigenin) is non-hormonal anabolic phytochemical noted to:

  • Increase protein synthesis
  • Boost IGF-1 and IGF-2
  • Enhance muscle growth
  • Regulate cortisol
  • Controls estrogen-promoting enzymes aromatase and 17β-HSD

Combined, these effects elevate Apisterone™ (Apigenin) into a class all its own among natural muscle builders.

Now, let’s take a deeper look into how this remarkable phyto-compound works.


Apisterone™ (Apigenin) (4′, 5, 7, -trihydroxyflavone,) is a flavone found in Chrysanthemum morifolium and other food materials.

Flavones are bioactive compounds within plants that exert a wide range of biological effects. Apisterone™ (Apigenin) in particular has been noted in various research trials to offer anti-inflammatory, anti-carcinogenic, and antioxidant properties.[3,6,11]

Due to these effects, researchers have begun studying the compound as an adjunct therapy to help combat the development of cancer due to its high selectivity of malignant cells.[7,8]

That’s great and all, but what does this have to do with me and my gains?

While much of the research to date has focused on the antioxidant and disease-combatting properties of Apisterone™ (Apigenin), more recent research has been investigated for the powerful phytochemical for its muscle-building potential.



The mechanistic target of rapamycin (mTOR) is the pathway in the body that drives muscle protein synthesis. It can be activated by a number of means including amino acids (leucine), insulin, and various growth factors.

Apisterone™ (Apigenin) has been documented to significantly increase muscle protein synthesis via increased phosphorylation of several key players in the mTOR pathway, including Akt, S6K1, and 4E-BP1.[1]

But that’s not all, Apisterone™ (Apigenin) also has been noted to increase expression of protein Prmt7 -- a major regulator of muscle mass.


As we mentioned above, a number of growth factors are capable are stimulating mTOR in the body. Insulin-like growth factor (IGF) is one such factor. More specifically, both two subtypes of IGF, in IGF-1 and IGF-2, regulate skeletal muscle development and regeneration, positively affecting hypertrophy (e.g. bigger, better gains and muscle growth).

Apisterone™ (Apigenin) has been noted to up-regulate expression of both IGF-1 and IGF-2 in studies, resulting in greaters muscle size and thickness.[1]


As you might expect, any compound that ramps up protein synthesis in the body has the potential to deliver extreme muscle growth, and that’s exactly what researchers observed with Apisterone™ (Apigenin).

The same researchers who documented increased protein synthesis from apigenin administration also observed noticeable increases muscle size and function. More specifically, subjects receiving Apisterone™ (Apigenin) gained thickness in the quadricep and saw an increase in running performance.[1]

Researchers noted these muscle gains were due to enhanced myogenic differentiation, increases in the nucleus ratio in myotubes (muscle fibers), and increased phosphorylation of p38 MAPK.[1]

Why is this important?

P38 MAPK is a major regulator of skeletal muscle development.[10]

It’s also worth noting that these increases in muscle size came without increases in total body weight, heart size/weight, subcutaneous fat, or liver weight.[1]

This makes Apisterone™ (Apigenin) extremely alluring as a potential muscle growth supplement for natural lifters looking to eek out every last bit of gains from the genetics.


In addition to its potential to help you build more muscle faster, Apisterone™ (Apigenin) may also be a testosterone amplifier.

Research indicates that Apisterone™ (Apigenin) can inhibit both aromatase and 17β-hydroxysteroid dehydrogenase (17β-HSD). As you may know, aromatase is the enzyme that catalyzes the conversion of testosterone to estradiol (an estrogen).

Perhaps most intriguing is Apisterone™ (Apigenin) unique ability to inhibit 17β-HSD, something that has only been accomplished naturally with three other flavonoids -- chrysin, genistein and naringenin.[4]


Cortisol is the body’s primary stress hormone released when we encounter threatening situations, such as a heavy set of back squats. While some cortisol is beneficial and necessary, chronically elevated levels of the hormone can lead to significant reductions in testosterone as cortisol and testosterone have an inverse relationship, meaning when one is high, the other is low and vice versa.

Cell culture studies using human adrenal cells note reductions in cortisol levels when exposed to apigenin.[9] Additionally, Apisterone™ (Apigenin) also prevents a key cortisol-producing enzyme, CYP11B1, from working properly.[12]

As a result, higher doses of Apisterone™ (Apigenin) have been noted to lower cortisol levels as well as offer anxiolytic and antidepressant-like effects.[5,6]

Together, these benefits make Apisterone™ (Apigenin) extremely alluring as a natural muscle-builder, which is why Killer Labz has included it in its newest anabolic agent...


LaxoBulk - Apisterone™

Killer Labz LaxoBulk features 20mg of Apisterone™ (Apigenin), our premium quality apigenin extract containing 98% pure apigenin. Also included in each serving of LaxoBulk is Laxosterone (Laxogenin) at a robust 100mg per serving along with DecaSorb technology to improve bioavailability and absorption.

Together, the combination of Apisterone™ (Apigenin) and Laxosterone (Laxogenin) position LaxoBulk as the leading natural anabolic supplement on the market for those wanting extreme muscle growth.


  1. Jang, Young J., et al. "Apigenin enhances skeletal muscle hypertrophy and myoblast differentiation by regulating Prmt7." Oncotarget, vol. 8, no. 45, 2017.
  2. Li W, Pandey AK, Yin X, et al. Effects of apigenin on steroidogenesis and steroidogenic acute regulatory gene expression in mouse Leydig cells. J Nutr Biochem. 2011;22(3):212-8.
  3. National Center for Biotechnology Information. PubChem Compound Database; CID=5280443, https://pubchem.ncbi.nlm.nih.gov/compound/5280443
  4. Le Bail JC , et al. "Aromatase and 17beta-hydroxysteroid Dehydrogenase Inhibition by Flavonoids. - PubMed - NCBI." National Center for Biotechnology Information, www.ncbi.nlm.nih.gov/pubmed/9929167.
  5. Nakazawa, T., Yasuda, T., Ueda, J., & Ohsawa, K. (2003). Antidepressant-like effects of apigenin and 2,4,5-trimethoxycinnamic acid from Perilla frutescens in the forced swimming test. Biological & Pharmaceutical Bulletin, 26(4), 474–480.
  6. Fahad Ali, Rahul, Falaq Naz, Smita Jyoti & Yasir Hasan Siddique (2017) Health functionality of apigenin: A review, International Journal of Food Properties, 20:6, 1197-1238, DOI: 10.1080/10942912.2016.1207188
  7. Gates MA, Vitonis AF, Tworoger SS, et al. Flavonoid intake and ovarian cancer risk in a population-based case-control study. Int J Cancer. 2009;124(8):1918-25.
  8. Gupta S, Afaq F, Mukhtar H. Selective growth-inhibitory, cell-cycle deregulatory and apoptotic response of apigenin in normal versus human prostate carcinoma cells . Biochem Biophys Res Commun. (2001)
  9. Ohno, S., Shinoda, S., Toyoshima, S., Nakazawa, H., Makino, T., & Nakajin, S. (2002). Effects of flavonoid phytochemicals on cortisol production and on activities of steroidogenic enzymes in human adrenocortical H295R cells. The Journal of Steroid Biochemistry and Molecular Biology, 80(3), 355–363.
  10. Keren, A., Tamir, Y., & Bengal, E. (2006). The p38 MAPK signaling pathway: a major regulator of skeletal muscle development. Molecular and Cellular Endocrinology, 252(1–2), 224–230. https://doi.org/10.1016/j.mce.2006.03.017
  11. Venigalla M, Gyengesi E, Münch G. Curcumin and Apigenin - novel and promising therapeutics against chronic neuroinflammation in Alzheimer's disease. Neural Regen Res. 2015;10(8):1181-5.
  12. Cheng, L.-C., & Li, L.-A. (2012). Flavonoids exhibit diverse effects on CYP11B1 expression and cortisol synthesis. Toxicology and Applied Pharmacology, 258(3), 343–350. https://doi.org/10.1016/j.taap.2011.11.017